Poxvirdae Rachyl Rackin

Commonly known as orthopox, poxvirus or smallpox

Double stranded DNA virus, which affects humans, domestic animals and insects. This virus has a large genome.
  • It's replication occurs in the cytoplasm.
  • Receptors for the virus replication are still unknown
  • penetration of the cell is complex and involves many mechanisms.
  • outer membrane is removed from the virus enters the cell
  • membrane is further removed as it enters the cytoplasm and is shed to the core
  • The virus expresses genes both before and after genome replication
  • gene replication is self priming
  • infected cells are then cleaved and reproduce

Virus to Vaccine

  • Jenner found that a small exposure to the cow pox virus made people immune to smallpox
  • First use of weakened virus' as a vaccine
  • first major disease to be eradicated in humans

Pox Characteristics

  1. Largest and debatably most complex virus
  2. linear, double stranded DNA
  3. Wide range of hosts
  4. Divided into two subfamilies: Chordopoxvirinae and Entomopoxviridae

Cashin-Garbutt, A. (2012, October 04). Virus Uses. Retrieved January 30, 2017, from http://www.news-medical.net/health/Virus-Uses.aspx

Hughes, A. L., Irausquin, S., & Friedman, R. (2010, January). The Evolutionary Biology of Poxviruses. Retrieved January 30, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818276/

Poxviridae. (2009, January 09). Retrieved January 30, 2017, from http://virology-microbiology-b.blogspot.com/2009/01/poxviridae.html

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