Progeria is a rare, fatal genetic condition of accelerated aging in children. Only 80 children in the world currently have the condition, including 18 in the United States, according to the Progeria Research Foundation. Children are born seemingly healthy, but start aging dramatically by the age of 2. On average, they die at 13. HGPS is caused by a mutation in the gene called LMNAThe LMNA gene produces the lamin A protein which is the structural scaffolding that holds the nucleus of a cell together. The abnormal lamin A protein that causes Progeria is called progerin. hair loss, delayed tooth development, enlarged head, hearing loss, high-pitched voice, incomplete sexual maturation, joint stiffness, loss of muscle, osteoarthritis, or taut skin. They test for LMNA mutations. There is no cure for this disease, but there are medications that help with the symptoms. there is no way to lower to risk.