A Message from Dr. Metz
Summer is always a time of transitions in our department with the combination of graduations and new team members joining Penn radiation oncology. Make sure to stop and introduce yourselves to new faces and make our new additions feel welcome. Also, during this time of transitions we need to be diligent in our quality and safety programs and educate our new team members of our approach, policies, and procedures. We will be increasing the frequency of this newsletter with the rapid pace of developments in the department. It is great to see our team embracing this platform and submitting updates and photos. We could not put this together without your engagement! Have a great rest of the Summer!!
Residents' Graduation 2019
In the News
Penn Receives $12 Million Grant to Study Connection between Radiation and Immunotherapies
The Mark Foundation for Cancer Research has established the Mark Center for Immunotherapy, Immune Signaling, and Radiation at the University of Pennsylvania. Penn Medicine and the Mark Foundation signed the grant on Friday, May 31, 2019 and named Andy Minn, MD, PhD, associate professor of Radiation Oncology, the Director of the Center. Two of the five projects will bring together multidisciplinary teams involving FLASH radiation and will enable ground breaking work by many members of our Department. Please click on the links below to read press release of this announcement as well as an article about the announcement in the Philly Voice.
StoryCorps Features Penn Radiation Oncology
New Department Logo
As you know, our Department has been growing and evolving in many exciting directions and will continue to do so as we continue to transform the world of radiation oncology as leaders in our field. This new logo will differentiate our Department as a brand, the Penn brand of Radiation Oncology that will be recognized throughout the world in the work all of you do every day. This is a logo that represents the strength and leadership of our Department as a whole so be sure to share it with pride in all of your outreach. Thank you for all of the work you do to put Penn Radiation Oncology in such a strong position as we continue to stake our claim as leaders in our field. We have a very bright future ahead.
Save the Date: Department Holiday Party
We Need Your Photos!
This year's holiday party will feature a scrolling slide show that will include photos of RadOnc employees from the past year. These can be from conferences, department events, or casual get-togethers with colleagues. Please submit your photos to RadOncPhotoSharing@pennmedicine.upenn.edu
Radiation Oncology New Hire Department Orientation
RadOnc department orientation takes place twice a year. If you are new to the Radiation Oncology department as of January 2019, you must attend (1) of the sessions listed below.
Please send your name or the name of your new hire, (If you are a manager), along with the preferred session to Renee Bates (Aretha.Bates2@pennmedicine.upenn.edu).
Tuesday, August 27, 2019 12:00 Noon – 4:00 PM - PCAM 12 South Room 12-166 - lunch will be provided
Wednesday, August 28, 2019 8:00 AM – 12:00 - PCAM 11 South Room 11-167 - breakfast will be provided
ASTRO Supplement Submissions
This year’s ASTRO 2019 will be held from September 15-18, in Chicago, IL. If you have not already done so, and you are planning to attend and will be featuring your poster at this event, please submit the information listed below pertaining to your presentation as soon as possible to Peri Niskey (Peri.Niskey@pennmedicine.upenn.edu) so it can be featured in our ASTRO 2019 Supplement.
This year we want to see you at ASTRO! For the first time, please submit a photo of yourself giving a talk or presenting your poster to be included in an upcoming edition of Spotlight. Send your photos to RadOncSpotlight@uphs.upenn.edu
RadOnc Research Speaker Seminar Series 2019-2020
Upcoming Department Art Exhibit
Earlier this year we had a very successful art show where medical physics brought their artistic talent into the spotlight. The result of this exhibit is now beautifully displayed in the hallways of our department. Many of the artists from our department expressed interest in participating in a future show, so this year a new exhibit is being organized by Andrea Dimofte that will be open to physics, physicians and dosimetrists. Everyone is invited to send up to 5 art pieces (in the form of photography or paintings) by August 24th, 2019. The best 35 submissions will be part of the new annual RadOnc show (a juried exhibit), at the Burrison Gallery. The exhibit dates will be September 28th through November 6th, culminating with a reception on October 4th, 2019. Please send the pictures to firstname.lastname@example.org by August 24th, 2019.
Meet the Newest Members of Our Team!
David joins our department as a Clinical Research Coordinator at PCAM. In his prior role, he was a Manager for Scheduling, and he has completed his Bachelor's of Science degree. In his spare time, David enjoys board games and stained glass. Contact David at email@example.com
Stephanie joins our department as a Radiation Therapist in Doylestown. In her prior role, she was working part time at Valley Forge and has a bachelors degree in Radiation Therapy from Gwynedd Mercy University. Contact Stephanie at Stephanie.firstname.lastname@example.org
Marc joins our department as a Financial Analyst at PCAM. In his prior role, he was at Dechert LLP and has a Bachelor of Business Administration degree. In his spare time, Marc enjoys travelling, reading, and photography. Contact Marc at email@example.com.
Jessica joins our department as a Patient Service Coordinator at CCH. In her prior role, she was a Patient Services Associate in Valley Forge and has a Bachelor’s degree in Psychology from Drexel. In her spare time, Jessica enjoys painting in oil, playing with her husky/pitbull puppy, and travelling. Contact Jessica at firstname.lastname@example.org
Scott joins our department as a Physicist at PCAM. In his prior role, he was a pedical physics resident in our department and has his PhD in Medical Physics, MD Anderson UTHealth Graduate School of Biomedical Sciences. Contact Scott at email@example.com
Amanda joins our department as a social worker at PCAM. In her prior role, she worked as an oncology social worker at the Tate Cancer Center at the University of Maryland Baltimore Washington Medical Center. Contact Amanda at Amanda.firstname.lastname@example.org
TyZhay joins our department as an Accountant at PCAM. In his previous role, he was a temporary accountant within our department and has a degree in accounting from the University of Pittsburgh at Johnstown. In his spare time, TyZhay enjoys basketball and photography. Contact TyZhay at Tyzhay.Scott@pennmedicine.upenn.edu
Christina joins our department as a Lead Radiation Therapist at Doylestown. In her prior role, she was a Radiation Therapist at Chester County and has a Bachelor’s degree in Health Care Administration from Gwynedd Mercy University/ARRT. Contact Christina at Christina.email@example.com
Samantha joins our department as a Financial Service Representative at CCH. In her prior role, she worked as a Quality Care Coordinator and has a degree in Heath Care Management. Contact Sammy at Samantha.Okoorian@pennmedicine.upenn.edu
Shelley joins our department as a staff assistant at PCAM. In her prior role, she worked in development at Congregation Rodeph Shalom. In her spare time, she teaches yoga and enjoys baking. Contact Shelley at firstname.lastname@example.org
Chester County Hospital Polo Club Event - June 9, 2019
RadOnc CCH supported this event benefitting the Ob/Gyn Clinic at Chester County Hospital and The Women's Auxiliary's Heart to Heart pledge to support the advancement of the Heart and Vascular Program at Chester County Hospital.
21st Annual Challenge for Cancer Bike Tour - June 23, 2019
Presented by Brandywine Valley Heat and Air Conditioning, this annual event benefits the Abramson Cancer Center at Chester County Hospital. Radiation Oncology was represented by Roseann Scamuffa, Marcella Kubovsak, and Eileen McDevitt at the event.
ACES Presents: Ice Cream PHILL Up - July 18, 2019
Just in time for the hottest week of the summer! Senior Managers and ACES Committee members at PCAM scooped up some ice cream for all faculty, staff, and students to enjoy while catching an inning or two of the Phillies game versus the Dodgers. We like to think that RadOnc's team spirit was felt all the way to Citizens Bank Park and helped lift the Phillies to a 7-6 win over the Dodgers!
Around the Network
Welcome Lancaster General RadOnc to Enterprise Aria System
On Monday, June 16 we welcomed LG Radiation Oncology to the enterprise Aria system with successful delivery of radiation treatment to the first patients! Congratulations to the team on achieving this major project milestone.
PAH Survivors Day
On May 31, PAH celebrated Survivors Day. Survivors Day was a day to celebrate our patients and show our support of them in ways other than giving them treatments. We provided gifts, games, refreshments and a time for our patients to get to know one another and show them how they support each other.
Funded by the University of Pennsylvania Global Education Fund (PI. Stephen Avery), the Global Health Catalyst Summit Tanzania was a resounding success with one outcome being increased support for GO-University. The summit also provided training to medical physicists, radiation oncologists and radiation therapists.
Global Health Catalyst Summit - Tanzania
Funded by the University of Pennsylvania Global Education Fund (PI. Stephen Avery), the Global Health Catalyst Summit Tanzania was a resounding success with one outcome being increased support for GO-University. Cordelia Baffic assisted the program administration for this international event. The summit also provided training to medical physicists, radiation oncologists and radiation therapists. Partners for this summit included UPENN, Harvard, University of Heidelberg, Muhimbili University of Health and Allied Science, Ocean Road Cancer Institute, the Federation of African Medical Physicists, AORTIC, amongst others. The Summit occurred from April 1st - April 4th, 2019.
British Ambassador's Visit to Philadelphia
Sir Nigel Kim Darroch spoke on the important trade relationship between our region and the United Kingdom, as well as the current political and economic climate during a lunch on May 20, 2019.
Mexican Ambassador's Visit to Philadelphia
Panel Discussion and meetings with community leaders and strategic allies hosted by the Philadelphia Consulate of Mexico during a Topical Exchange with Ambassador from Mexico, Martha Barcena-Coqui on March 8, 2019.
Here at Home: Global Education Program
Amirshaghaghi A, Yan L, Miller J, Daniel Y, Stein JM, Busch TM, Cheng Z, Tsourkas A. Chlorin e6-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters as a Theranostic Agent for Dual-Mode Imaging and Photodynamic Therapy. Sci Rep. 2019 Feb 22;9(1):2613 PMID: 30796251
Baumann BC, Lustig RA, Mazzoni S, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Both S, Lin A, Dorsey JF, Alonso-Basanta M. A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment. J Surg Oncol. 2019 May 20. PMID: 31111502
Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM; Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups. Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. J Immunother Cancer. 2019 May 22;7(1):131. PMID: 31113486
Berger I, Cengel KA, Simone CB 2nd, Alley EW, Roshkovan L, Haas AR, Patel AM, Khalid U, Culligan MJ, McNulty S, Singhal S, Friedberg JS, Katz SI. Lymphangitic carcinomatosis: A common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma. Lung Cancer. 2019 Jun;132:94-98. PMID: 31097101
Dreyfuss AD, Bravo P, Koumenis C, Ky B. State of the Art: Precision Cardio-Oncology. J Nucl Med. 2019 Jan 17. PMID: 30655328
Olivia M Giza, Daniel Sánchez-Parcerisa, Víctor Sánchez-Tembleque, Joaquin L Herraiz, Jorge Camacho, Stephen Avery and José Manuel Udías: Photoacoustic dose monitoring in clinical high-energy photon beams. Biomedical Physics & Engineering Express 5(3), April 2019
Grewal AS, Schonewolf C, Min EJ, Chao HH, Both S, Lam S, Mazzoni S, Bekelman J, Christodouleas J, Vapiwala N. Four-Year Outcomes From a Prospective Phase II Clinical Trial of Moderately Hypofractionated Proton Therapy for Localized Prostate Cancer. Int J Radiat Oncol Biol Phys. 2019 Jun 11.[Epub ahead of print]
Hu Z, Zhou J, Jiang J, Yuan J, Zhang Y, Wei X, Loo N, Wang Y, Pan Y, Zhang T, Zhong X, Long M, Montone KT, Tanyi JL, Fan Y, Wang TL, Shih IM, Hu X, Zhang L. Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment. Nat Commun. 2019 Feb 13;10(1):733 PMID: 30760718
Khatri, U., Waldner, A., LaRiviere, M.J., Weaver, M., Lynn, J., Sanchez, S., Shofer, F., Todd, B., Aysola, J. An Evaluation of Implicit Bias Training in Graduate Medical Education. MedEdPublish. 8(2):39.
Kim M, Irmen P, Shoniyozov K, Verginadis II, Cengel KA, Koumenis C, Metz JM, Dong L, Diffenderfer E. Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Phys Med Biol. 2019 May 10. PMID: 31075786
LaRiviere, M.J., Zhu, T.C., Christodouleas, J.P. Important technical considerations for implementing the ASTRO/ASCO/AUA prostate cancer hypofractionated radiation guideline. Practical Radiation Oncology. 2019 Jul - Aug;9(4):197-199.
LaRiviere, M.J., Baumann, B., Christodouleas, J. Bladder Cancer. Gunderson & Tepper: Clinical Radiation Oncology, 5e. Elsevier. Accepted.
Michael J. LaRiviere, Robert A. Avery, J. Gregory Dolan, Peter C. Adamson, Deborah M. Zarnow, Yunhe Xie, Stephen M. Avery, Goldie A. Kurtz, Christine E. Hill-Kayser, Robert A. Lustig, J. Nicholas Lukens: Emergent radiation for leukemic optic nerve infiltration in a child receiving intrathecal methotrexate. Practical Radiation Oncology In Press, April 2019.
LaRiviere, M.J., Santos, P.M.G., Hill-Kayser, C.E., Metz, J.M. Proton Therapy. Hematology/Oncology Clinics of North America. Peer-reviewed review. Accepted.
Mahmoudi K, Garvey KL, Bouras A, Cramer G, Stepp H, Jesu Raj JG, Bozec D, Busch TM, Hadjipanayis CG. 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas. J Neurooncol. 2019 Jan 18. PMID: 30659522
R L Maughan, S Avery, E S Diffenderfer, D Dolney and B-K K Teo : Recent developments at the University of Pennsylvania's Roberts Proton Therapy Center. Journal of Physics: Conference Series 1154, May 2019
Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY. An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer Cell. 2019 Jan 14;35(1):33-45. PMID: 30645975
Russell KL, Gorgulho CM, Allen A, Vakaki M, Wang Y, Facciabene A, Lee D, Roy P, Buchser WJ, Appleman LJ, Maranchie J, Storkus WJ, Lotze MT. Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium. Cancer J. 2019 May/Jun;25(3):165-177. PMID: 31135523
Sheikh S, Saxena D, Tian X, Amirshaghaghi A, Tsourkas A, Brem S, Dorsey JF. An integrated stress response agent that modulates DR5 dependent TRAIL synergy reduces patient derived glioma stem cell viability. Mol Cancer Res. 2019 Jan 14. PMID: 30642878
Tameire, Feven & Verginadis, Ioannis & Maria Leli, Nektaria & Polte, Christine & Conn, Crystal & Ojha, Rani & Salas Salinas, Carlo & Chinga, Frank & M. Monroy, Alexandra & Fu, Weixuan & Wang, Paul & Kossenkov, Andrew & Ye, Jiangbin & K. Amaravadi, Ravi & Ignatova, Zoya & Fuchs, Serge & Diehl, John & Ruggero, Davide & Koumenis, Constantinos. (2019). ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature Cell Biology. 1. 10.1038/s41556-019-0370-x
Vapiwala N, Thomas CR Jr, Grover S, Yap ML, Mitin T, Shulman LN, Gospodarowicz MK, Longo J, Petereit DG, Ennis RD, Hayman JA, Rodin D, Buchsbaum JC, Vikram B, Abdel-Wahab M, Epstein AH, Okunieff P, Goldwein J, Kupelian P, Weidhaas JB, Tucker MA, Boice JD Jr, Fuller CD, Thompson RF, Trister AD, Formenti SC, Barcellos-Hoff MH, Jones J, Dharmarajan KV, Zietman AL, Coleman CN. Enhancing Career Paths for Tomorrow's Radiation Oncologists. Int J Radiat Oncol Biol Phys. 2019 May 22
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