Parkinson's Disease

Parkinson's Disease is considered a progressive disorder which effects the brain and can create progressive tremors in the hands and other extremities, Parkinson's is a nervous system disorder which affects the Substantia Niagra

Often the first symptom of Parkinson is memory loss or trembling of the hands or other extremeties. It can also develop stiffness or rigidity of the limbs and memory loss, eventually it can lead to unstable breathing and lack of oxygen. Most cases of Parkinson's develops with a complex interaction of the environmental and genetic materials. Approximately 15 percent of people with Parkinson disease have a family history of this disorder. Parkinson disease can be attributed to by changes in the LRRK2, PARK2, PARK7, PINK1, or SNCA gene, or by alterations in genes that have not been identified. It is not fully understood how genetic changes cause Parkinson disease or influence the risk of developing the disorder. Almost all symptoms originate from the substantia niagra in the brain. Some gene mutations appear to disturb the cell machinery that breaks down unwanted proteins in dopamine-producing centers. As a byproduct of energy production, mitochondria make unstable molecules called free radicals that can damage cells which can lead to the symptoms of parkinson's. Most cases of Parkinson disease occur in people with no apparent family history of the disorder. These sporadic cases may not be inherited, or they may have an inheritance pattern that is not known. If the PARK2, PARK7 or PINK1 gene is involved, Parkinson disease is inherited in an automatic recessive pattern. This type of inheritance means that two copies of the gene in each cell are changed. Most often, the parents of an individual with automatic recessive Parkinson disease each carry one copy of the altered gene but do not show signs and symptoms of the disorder.

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