After many years of the English using the Natives and Africans as slaves for their plantations, mass amounts of slaves were miss treated and tortured and killed. After Columbus found the "New World" he raped and killed many of the natives, when he left he told the English and Spanish about his voyage in which they set their own voyages and used the land as a plantation for sugar. The English took the natives as slaves and forced them to work on the plantation or be killed. Bartolome da Casas sent a letter to Spain saying that the natives were being "miss treated" and "tortured", his solution to the problem was to quit using the natives as slaves and transport slaves from Africa. Bartolome was the reason the nations used Africans as slaves.
English conflicts with spanish and Turks
The English conflicts between Spain and Ottoman Empire was after the fall of Constantinople, the Turks forced England out of the silk route making it harder for the English to get the spices and other materials they desperately needed. After England was out of the silk route Spain got more money and started the Reconquista which gave them enough money to pay for their armies and to send the extra money elsewhere. This threatened England because Spain was more powerful and would be harder to defeat.