Alzheimers By: Bailey Peters and Rachel Galyen

What is Alzheimer's Disease?

Alzheimer's Disease is the overproduction of amyloid plaques and neurofibrillary chemicals within the brain's nerve cells. This causes nerve cells to lose connection; causing them to die. While Alzheimer's is an inherited disease; the probability of someone inheriting it from a family member with past history is 50/50. Alzheimer's causes the victim to lose memory over time. This causes them to forget how things work, who people are, and what is realistic. It almost causes them to resemble a small child in their way of thinking.

What Causes Alzheimer's Disease?

Alzheimer's Disease is caused by a change in one of three chromosomes. Each chromosome can be changed, but will affect the victim in different ways. A change in chromosome 21 produces abnormal amyloid precursor proteins which can be broken down making harmful amyloid plaques, a change in chromosome 14 produces abnormal preslin 1, and a change in chromosome 1 produces abnormal preslin 2. The type of change occurred in these chromosomes are known as an Inversion in Chromosomal Mutation.

How to Diagnose someone with Alzheimer's Disease

In order to diagnose someone with Alzheimer's Disease, the best thing to do is to go to the doctor's. They may ask the patient about their health, past health, how they perform daly tasks, and if there have been any changes in personality or behavior. If they feel the need to progress in testing the doctor may also test the patient on memory, problem solving, attention, counting, and language. Careful diagnosing also includes blood and urine tests. Another form of testing using technology are brain scans. There are 3 types of brain scans; Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography. The doctors that perform these tests can be Geratricians, Geratric Psychiatrists, Neurologists, or Neuropsychologists. The tests performed can be repeated if needed. The only way to truly diagnose a patient is to examine their brain after death, but if you wanted a basic realistic guess, it would be best to go to the Alzheimer's Disease Research Center.

https://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-genetics-fact-sheet

Alzheimer's Disease Genetic Fact Sheet. (2016). Retrieved from https://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-genetics-fact-sheet

https://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-genetics-fact-sheet

What Treatments are Available:

There are several ways to go about helping Alzheimer’s. For behavioral changes, non-drug approaches are typically tried first. Steps to developing successful non-drug treatments include recognizing that the person is not just " acting mean or ornery, " but is having further symptoms of the disease, identifying the cause and how the symptom may relate to the experience of the person with Alzheimer's. Finally, changing the environment to resolve challenges and obstacles to comfort, security and ease of mind. For memory loss there are recommend drugs such as Donepzil, Galantamine, Memantine, Rivastigmine and

more.http://www.alz.org/alzheimers_disease_treatments.asp

Treatments for Alzheimer's disease. (2017). Retrieved from http://more.http://www.alz.org/alzheimers_disease_treatments.asp

Researchers are looking for new ways to treat Alzheimer's.Current drugs help mask the symptoms of Alzheimer's, but do not treat the underlying disease or delay its progression. There are several promising drugs in development and testing, but more volunteers are needed to complete clinical trials of those drugs and increased federal funding of research to ensure thatfresh ideas continue to fill the

pipeline.http://www.alz.org/research/science/alzheimers_disease_treatments.asp

Current Alzheimer's Treatments. (2017). Retrieved from http://pipeline.http://www.alz.org/research/science/alzheimers_disease_treatments.asp

Is It Inheritable?

The early-onset form of Alzheimer disease is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person inherits the altered gene from one affected parent. People who inherit one copy of the APOEe4 allele have an increased chance of developing the disease; those who inherit two copies of the allele are at even greater risk. Although it is important to note that people with the APOE e4 allele inherit an increased risk of developing Alzheimer disease, not the disease itself.Not all people with Alzheimer disease have the e4 allele, and not all people who have the e4 allele will develop the disease.

https://ghr.nlm.nih.gov/condition/alzheimer-disease#inheritance

Alzheimer's disease. (2017). Retrieved from https://ghr.nlm.nih.gov/condition/alzheimer-disease#inheritance

Created By
Bailey and Rachel Peters and Gaylen
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Created with images by neil conway - "Brains" • Can H. - "Karyotype" • frolicsomepl - "blood medical attempts" • skeeze - "patient positiron emission tomography pet" • ElisaRiva - "head brain thoughts"

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