Silver is antifungal silver nanoparticles vs. pathogenic fungi

In vitro antifungal activity of silver nanoparticles against ocular pathogenic filamentous fungi.

J Ocul Pharmacol Ther. 2013 Mar;29(2):270-4. doi: 10.1089/jop.2012.0155. Epub 2013 Feb 14. Xu Y, Gao C, Li X, He Y, Zhou L, Pang G, Sun S.

"Fungal keratitis is emerging as a major cause of vision loss in a developing country such as China because of higher incidence and the unavailability of effective antifungals. It is urgent to explore broad-spectrum antifungals to effectively suppress ocular fungal pathogens, and to develop new antifungal eye drops to combat this vision-threatening infection." "Nano-Ag, relative to natamycin, exhibits potent in vitro activity against ocular pathogenic filamentous fungi."
Nano-Ag exerted activity on the mycelia

Antifungal effect of silver nanoparticles on dermatophytes.

J Microbiol Biotechnol. 2008 Aug;18(8):1482-4. Kim KJ, Sung WS, Moon SK, Choi JS, Kim JG, Lee DG.

"Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 microg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 microg/ml; fluconazole IC80, 10- 30 microg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications."
Antifungal effect against Candida albicans and Candida glabrata.

Silver colloidal nanoparticles: antifungal effect against adhered cells and biofilms of Candida albicans and Candida glabrata.

Biofouling. 2011 Aug;27(7):711-9. doi: 10.1080/08927014.2011.599101. Monteiro DR, Gorup LF, Silva S, Negri M, de Camargo ER, Oliveira R, Barbosa DB, Henriques M.

"In summary, SN may have the potential to be an effective alternative to conventional antifungal agents for future therapies in Candida-associated denture stomatitis."
Growth in all isolates was inhibited

Antifungal properties of electrically generated metallic ions.

Antimicrob Agents Chemother. 1976 Nov;10(5):856-60. Berger TJ, Spadaro JA, Bierman R, Chapin SE, Becker RO.

"The present study demonstrated that anodic silver (Ag(+)) at low direct currents had inhibitory and fungicidal properties. Broth dilution susceptibility tests were made on several species of Candida and one species of Torulopsis. Growth in all isolates was inhibited by concentrations of electrically generated silver ions between 0.5 and 4.7 mug/ml, and silver exhibited fungicidal properties at concentrations as low as 1.9 mug/ml. The inhibitory and fungicidal concentrations of electrically generated silver ions are lower than those reported for other silver compounds."
Disruption of the structural layers of the outer fungal cell wall

Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study.

J Nanobiotechnology. 2015 Dec 15;13:91. doi: 10.1186/s12951-015-0147-8. Lara HH, Romero-Urbina DG, Pierce C, Lopez-Ribot JL, Arellano-Jiménez MJ, Jose-Yacaman M.

"Our results demonstrate that silver nanoparticles are potent inhibitors of C. albicans biofilm formation. SEM observations are consistent with an overall loss of structure of biofilms mostly due to disruption of the outer cell membrane/wall and inhibition of filamentation.TEM indicates the permeabilization of the cell wall and subsequent disruption of the structural layers of the outer fungal cell wall. The anti-biofilm effects are via cell wall disruption."
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SilverLife Division of MediTec Group
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Created with images by fireflythegreat - "Fungus" • USDAgov - "d2641-3" • Iqbal Osman1 - "Fungal elements" • Iqbal Osman1 - "Fungal Hypahe on wet prep" • MichaelFrancisco - "Candida albicans (1000X magnification)"

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