- Meriwether Lewis - Lead the expedition and was an American Explorer.
- William Clark - He was an american explorer, plantation owner, and slave owner
- Sacagawea - Part of the Shoshone tribe, she was Lewis and Clark's interpreter. She helped them a lot.
Thomas Jefferson - He told Lewis and Clark what to do, and was the one who paid for the expedition.
Benjamin Rush - He was a well known doctor and taught them some tricks for being a doctor on the trip.