Duchenne Muscular Dystrophy Rachael driskell

WHAT: Duchenne Muscular Dystrophy is a x-linked recessive mutation. This means that it is passed on by the mother and is almost only symptomatic in males.

CAUSE: Duchenne Muscular Dystrophy can only occur in females because the mutation forms when 1 X-Chromosome contains a normal dystrophin gene, and the other X-Chromosome contains the mutated dystrophin gene. This is why only women are carriers, but rarely show symptoms.

WHAT IS DYSTROPHIN: Dystrophin is a protein that lies within the cell membranes of the muscles. Its purpose is to allow muscles to maintain their elasticity and strength. Without this protein, muscles become weak, nonfunctional, and eventually stop working.

WHERE: Once diagnosed with muscular dystrophy, muscle weakness will typically begin around age 4. The loss of strength will first begin in the upper legs and pelvis, and then will be followed by the upper arms. Most children are unable to walk by age 12 and the average life expectancy is 26.

WHO: Duchenne Muscular Dystrophy was first described by a French neurologist named Guillaume Benjamin Amand Duchenne in the 1860s. Duchenne's is 1 of 9 different types of muscular dystrophy. There is no known cure.

WORKS CITED

"Duchenne muscular dystrophy." Wikipedia. Wikimedia Foundation, 04 Apr. 2017. Web. 07 Apr. 2017.

"Duchenne Muscular Dystrophy (DMD)." Muscular Dystrophy Association. N.p., 20 Sept. 2016. Web. 07 Apr. 2017.

"Learning About Duchenne Muscular Dystrophy." National Human Genome Research Institute (NHGRI). N.p., n.d. Web. 07 Apr. 2017.

Credits:

Created with images by Hey Paul Studios - "Framed Embroidery Chromosome Art" • Thomas Fisher Rare Book Library, UofT - "Muscles" • IsaacMao - "Brain" • blickpixel - "cable computer sata"

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