In 1952 3,145 people died from polio and 21,269 were left with paralysis. it was decreased 99% since 1988, more than 350,000 cases to 74 reported cases on 2015, 2 countries in the world have never stopped the transmission of an and Afghanistan. 1-200 infections leads to paralysis. 5 to 10 percent die when their breathing muscle become immobilized.
Polio can affect the spinal cord causing muscle weakness and paralysis. It enters the body through the mouth. It multiples in the throat and gastrointestinal tract, then moves into blood stream and is carried to central nervous system where it replicates and destroys the moter neuron cells. (controls swallowing, circulation, respiration, arms and legs) The virus then makes thousands of copies of itself and effects other cells.
It’s estimated that 95 to 99 percent of people who contract polio are asymptomatic. This is known as subclinical polio. Even without symptoms, people infected with polio can still spread the virus and cause infection in others.
Signs and symptoms of non-paralytic polio can last from one to 10 days. These signs and symptoms can be flu-like and can include fever, sore throat, headache, vomiting, fatigue, and meningitis
Oral polio vaccine (OPV) is a live-attenuated vaccine, produced by the passage of the virus through non-human cells at a sub-physiological temperature, which produces spontaneous mutations in the viral genome.