Wednesday, August 14, 2019

380 S. University Avenue, Hill Pavilion and Lobby, Philadelphia, PA 19104

8:30 a.m.-5:00 p.m.

In 1994, Dr. Ralph Brinster at Penn Vet published his landmark discovery of Spermatogonial Stem Cell (SSC) transplantation, thereby transforming the fields of reproductive biology and regenerative medicine. To mark the 25th anniversary of SSC transplantation, we have planned an one-day symposium for scientific exchange among students, faculty, and researchers. The theme will be “IRM/Penn Vet: Frontiers of Germ Cell Research”. The symposium will include talks from Penn faculty members that highlight collaborative research projects and feature national and international speakers discussing emerging areas of germ cell research. The talks will fall within the global one health initiative: “One health, many species”, featuring research in mice, domestic large animals, primates, and humans. The keynote speaker will be Dr. David Page, Director of Whitehead Institute and a pioneer in genomics of sex chromosomes. The symposium is free to all attendees and open to all researchers inside and outside of University of Pennsylvania. Overall the symposium will provide a unique platform for integrating knowledge and exploring new frontiers in the field.


MONDAY, JULY 15, 2019


The symposium is sponsored by Penn's Institute of Regenerative Medicine (IRM), Penn's School of Veterinary Medicine, Center for Research on Reproduction and Women’s Health, and the Penn Center for Study of Epigenetics in Reproduction.


8:00 - 8:45 Registration & Breakfast

8:45 - 9:00 Welcome: Jeremy Wang, MD/PhD

Opening Remarks: Dean Andrew Hoffman, DVM, DSc

9:00 - 9:30 Opening Address (Introduction by Dean Hoffman)

Ralph Brinster, VMD, PhD

Spermatogonial stem cell overview

Session 1: Foundation and Applications of SSC Transplantation

Chair: Jeremy Wang

9:30 - 10:00 Ina Dobrinski, DVM, PhD

Germ cell transplantation and beyond: applications in large animal models

10:00 - 10:30 Jon Oatley, PhD

Surrogate sires: germline transplantation to enhance livestock production

10:30 - 10:45 Coffee Break

10:45 - 11:15 Jurrien Dean, MD

Spermatogonial stem cells, piRNA and monospermic fertilization

11:15 - 11:45 Takashi Shinohara, PhD

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation: Long live the spermatogonial stem cells!

11:45 - 12:15 Sandra Ryeom, PhD

Fertility preservation for pre-pubertal boys after chemotherapy-induced infertility

12:15 - 1:15 Lunch in H132 and Hill Pavilion Lobby

Session 2: Emerging and Translational Research

Chair: Marisa Bartolomei, PhD

1:15 - 1:45 Kotaro Sasaki, MD/PhD

In vitro gametogenesis in humans

1:45 - 2:15 Sue Hammoud, PhD

The power of one: novel perspectives of single-cell technologies in gametogenesis

2:15 - 2:45 Monica Mainigi, MD

Assisted reproductive technologies and adverse perinatal outcomes: The what, why & HOW?

2:45 - 3:15 Kyle Orwig, PhD

Stem cell therapies for male infertility

3:15 - 3:30 Coffee Break

3:30 - 3:45 Introduction of Dr. Page by Christos Coutifaris, MD.

3:45 - 4:45 Keynote Lecture

David Page, MD

Mammalian germ cells are determined after PGC colonization of the genital ridge

4:45 - 5:00 Closing Remarks: Ken Zaret, PhD

5:00 - 6:00 Reception

Opening Address: Dr. Ralph Brinster, Richard King Mellon Professor of Reproductive Physiology, National Medal of Science Recipient 2010

Keynote Speaker: Dr. David Page, Whitehead Institute, HHMI, and M.I.T.


Dr. Jurrien Dean, National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK)

Dr. Ina Dobrinski, University of Calgary

Dr. Sue Hammoud, University of Michigan

Dr. Monica Mainigi, University of Pennsylvania Perelman School of Medicine

Dr. Jon Oatley, Washington State University

Dr. Kyle Orwig, University of Pittsburgh

Dr. Sandra Ryeom, University of Pennsylvania Perelman School of Medicine

Dr. Kotaro Sasaki, University of Pennsylvania School of Veterinary Medicine

Dr. Takashi Shinohara, Kyoto University

Organizing Committee: Marisa Bartolomei, Christos Coutifaris, Kotaro Sasaki, Jeremy Wang

Hotels on campus:

For additional information contact: Shivani Berry (shivani2@vet.upenn.edu)

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