Prices to Cape Town from Columbus seem to average around the $1,400 range, so it's pretty pricy. The cheapest tickets would be United Airlines roundtrip tickets for $1,337. The plane ride would last for 33 hours and 55 minutes and would take two stops.
The room prices seem to average around $350 per night at the Radisson Blu Hotel Waterfront. It's a beautiful hotel by the water with rooms that have views of Table Mountain and the ocean. There's also a spa and poolside bar.