Location of BRCA1 on chromosome 17
Protein: breast cancer type 1 susceptibility protein
When Was Breast Cancer Discovered?
Breast Cancer was first documented in Egypt around 3000-2500 BC. It was discovered earlier than most diseases because it affects an area that can be found by the person who has it.
Disease Incidence and Prognosis
In 2013, 230,850 women and 2,109 men were diagnosed with breast cancer and 40,860 women and 464 men died from breast cancer in the United States. 1.7 million cases of breast cancer were diagnosed worldwide in 2012.
Affect of mutated BRCA genes on the chances of developing breast cancer
Populations affected by Breast Cancer
Breast Cancer mostly affects women, but men also can get breast cancer although it is rare.
Genetic Pattern of Inheritance
The BRCA1 gene is autosomal dominant meaning only one of the parents has to have the gene in order for the offspring to have that gene and get the disease.
Possible Types of Mutations in the BRCA1 gene
Symptoms and Diagnoses
Symptoms include lumps caused by the tumor, changes in the size or shape of the breast, and discharges from the nipple. Breast cancer is diagnosed through screenings that can detect tumors and by the patient experiencing the symptoms of breast cancer.
- Radiation Therapy
- Hormone Therapy
- Targeted Therapy (using substances to attack cancerous cells, but not healthy cells)
Breast Cancer Research
Research is being made on many areas of breast cancer including
- Detecting mutations in the BRCA1 and BRCA2 genes
- Finding causes of breast cancer
- How to prevent/ reduce the risk of getting breast cancer
- New methods to detect breast cancer
- New treatments for breast cancer
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Location of the BRCA1 Gene on Chromosome 17. Genetics Home Reference, U.S. Department of Health and Human Services, 2017, ghr.nlm.nih.gov. Accessed 5 Feb. 2017.
Possible Types of Mutations in BRCA Genes. Royal Society of Chemistry, 2016, pubs.rsc.org/. Accessed 5 Feb. 2017.
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