Neuronal remodeling is the process of rewiring the neural wires (neurons). It is an outcome in response to any injury happened to the neural circuits for e.g:- any traumatic injury. It takes place within the biological system in the central as well as peripheral neuronal cells. It is a common response found in lowest class of animal kingdom to the higher organisms. Clinical manifestation in which we found the remarkable neuronal remodeling are the Traumatic brain injury, Parkinson Disease, Autism, Huntington disease etc. Neuronal remodeling lead to the new neural networks, which are not similar to the natural neural connections. Because, of which the phenotypic behavior of the patient is somewhat dissimilar compared to the initial normal state of the individual. There are some genetic factors responsible for the above phenomenon. Amongst those factors, it has been evidently reported that, (alan shepherd) Shep gene , responsible for the process of neuronal remodeling in Drosophila melanogaster (Fruit fly).
- Chen D, Qu C, Bjorum SM, Beckingham KM, Hewes RS. Neuronal remodeling during metamorphosis is regulated by the alan shepard (shep) gene in Drosophila melanogaster. Genetics. 2014 Aug 1;197(4):1267-83.