Jacqueline Casey was born April 1927 in Quincey, Massachusetts. Casey decided to study at MassArt (Massachusetts College of Art) where she earned a Bachelor of Fine Arts degree in fashion design and illustration.
After graduating in 1949, Casey worked in interior design and advertising before Muriel Cooper, a fellow MassArt graduate and designer, recruited her to work at the Office of Publications in MIT. When Cooper joined the faculty at MIT 1972, Casey took over as director.
Jacqueline Casey designed publicity posters for events at MIT which were known to be very distinctive.
Casey was influenced by the, newly developed, Swiss, International Typographic Style, a graphic design style which originated in Russia. Casey was also influenced by specific designers such as Karl Gerstner, Armin Hofmann and Josef Müller-Brockmann.