What are drugs? Drugs are a medicine or other substance which has a physiological effect when ingested or other wised introduced into the body. Over time drugs have evolved, for reasons of good and bad. At first, drugs were legal, and weren't seen for their harmful effects. But was used often at parties, and even in food. For example, the drink Coco Cola, was first made with the drug cocaine. Once people started realizing that cocaine was addictive and harmful the body, the Coco Cola company stopped making the drink with the drug, and is now known as a delicious sugary drink.