Mako uses HITI technology in vivo to remove faulty genes and replace them with healthy or functional genes. HITI is the new era of CRISPR/Cas9 technology which is developed as a gene-editing tool to modify DNA. The pictures she presents me with are: 1. a cartoon of DNA and CRISPR/Cas9 2. a picture of brain tissues taken under fluorescent microscopy. In these tissues, an exogenous gene was introduced using the HITI method. The blue cells indicate cell nuclei. The orange cells show incorporation of all HITI components. The yellow cells represent both green and orange. The green cells represent those cells where the exogenous gene has been successfully incorporated into the genome. This is the desired cell color.
It is time to run the first coat muslin test. Yay! The muslin fits.
Time to find a way to place the DNA inspired by picture 1 onto the coat.
I decide to digitize the DNA and embroider it on the back of the coat. Who better than my friend Ingrid Leake to help me with that? Like my counterpart Mako, Ingrid uses modern technology to digitize and sculpt the shape of the genetic material on the back of my kimono-esque coat.
Ok no problem. How about metallic threads? Pretty by themselves but utter failure when embroidered on the coat. Am I to regret the choice of fabric? I’m getting discouraged… Well how about embroidery and applique! After hours in three different fabric stores, I located this silk, green/orange and yellow fabric reminiscent of Mako’s microscope photo. We might have a winner. Five hours later, I am happy. The sample works! Onto embroidering the actual coat…
I have the technology concept down. The coat is done!
It's time to start working on the dress. Mako’s picture 2 is up . It makes me think of sunshine, poppy fields, flowers, spring green, youth, hope, on a canvas. Again, I’m thinking of a vaporous tulle skirt a la Christian Dior circa 1950’s sprinkled with flowers and butterflies and symbolizing the different cells. The coat is CRISPR/Cas9, which is the bold machine that cuts, opens and modifies double-strand DNA. The dress is the inside still a young field, engendering hope, spring, renewal.