Why is heme iron interesting? A SAFE AND EASY WAY OF SUPPLEMENTING

Heme iron is safe and natural

There are only two kinds of iron that we can use; heme iron from meat, poultry or fish and non-heme iron from vegetables, dairy products or chemically bonded iron in supplements. Synthetic non-heme iron in the standard iron preparations has a low degree of uptake and often produces unpleasant side-effects.

The natural bovine heme iron in OptiFer® is absorbed five times more efficiently than non-heme iron and has excellent tolerability. Today heme iron has seen safe use in the Swedish pharmacy for more than thirty years with literally millions of users. Bovine hemoglobin powder have no reported serious side-effects or poisonings at all reported during this time.

Food supplements with efficacy on par with prescription preparations

OptiFer® tablets can be dosed once daily 1-2 tablets without side-effects. They are more effective than any other iron preparation per elementary iron due to a superior absorption.

Most of the iron in synthetic tablets is not taken up due to due to simultaneously ingested other foodstuff or drink or the clinical condition. The natural uptake of heme iron is over 20 % whereas non-heme iron is taken up at best at 3 - 4%.

Efficacy of natural heme iron is far better than for synthetic non-heme forms. The heme iron uptake is 20 - 40 %, non-heme only 2 - 4 %. In clinical studies heme iron gives less than placebo levels of side-effects (it’s impossible to get below this), while non-heme supplements give often more than 20 – 30 % percent therapy-ruining and painful gastro-intestinal side-effects. The success of any iron therapy is closely related to user friendliness. This means that tolerance and dosage-related compliance is of central importance.

Well tolerated non-prescription supplement

OptiFer® tablets have less side-effects than any other iron preparation and can be dosed once daily 1 -2 tablets without side-effects. OptiFer® tablets have a high compliance due to excellent tolerability.

OptiFer® tablets naturally have an ideal slow release mechanism in themselves since the protein complex dissolves slowly. This gives a much-wanted steady and slow release of iron for an optimal intake and extremely low side effect risk. It also has a direct effect on compliance.

Heme iron preparations have a virtually perfect tolerance and this will not change over time, which is good news for chronics. Non-heme iron will sooner or later give side-effects that leaves the only remaining alternative, intravenously given iron. This however has risks in the form of oxidative stress on the organism besides being very expensive, painful and demanding clinical dosage.

Easy dosage

OptiFer® tablets have a normal dosage of 1 - 2 tablets per day. The tablet may be taken at any time during the day.

For chronics it's been shown that heme iron therapy is ideal since the efficacy or tolerance do not change over time. This is not the case for regular non-heme iron supplements.

Many chronics given intravenous iron are bound to visiting a clinic regularly. Heme iron tablet therapy is simple and gives for instance the freedom to travel.

Absorption steady and higher than for non-heme iron

The OptiFer® tablets erode over several hours, giving a slow and steady infusion of iron.

Absorption regardless of simultaneously ingested other medication, food or drink. Heme iron will be absorbed regardless of clinical condition.

A steady absorption is also important for constant uptake, since there is an upper limit when uptake is no longer efficient.

Safe and secure

Poisonings in children with oral high-dose non-heme iron products. With OptiFer there is a high level of security. It is unlikely that poisonings can happen with heme iron even for little children. The so-called Mucosa barrier that fails in sudden high-doses of ferric iron is not critical when using heme iron. The hemoglobin will not dissociate in gastric acid meaning that no free toxic iron ions will appear.

Heme iron in low doses is basically side-effects free. In all studies the side-effects level is around 10 %, which is identical to placebo.

Oral non-heme iron products are known to have a side-effects ratio of up to 30 %.

Large user groups

The biggest group for iron supplementation is found among all fertile females who lose blood through menses and need replacement. It is estimated that one in every four fertile women need continuing supplementation. This is the same in all countries globally

Secondary target buyer groups are pregnants and those planning pregnancy (folic acid counters certain birth-defects), the elderly and sports.

A large group of users is all who suffer from chronic diseases that are related to anaemia. E.g Chronic Kidney Disease - CKD, Inflammatory Bowel Disease - IBD, among others. Intravenous iron injections have been shown to be effective, the iron depots in the body are secured and blood genesis is more effective. Side-effects in conjunction with the injections are few but serious allergic reactions may appear. There are theoretical risks with iron injections over a longer period of time.

Researchers have found that intravenous iron injections cause periods of exacerbation of oxidative stress in the circulation. Additionally the iron content in the body is often too high, which is associated with chronic inflammation and vascular damage.

Target groups for marketing include General practitioners, Gynaecologists, Midwives, Nurses and personnel within jobplace healthcare (including school health). They are the ones that diagnose anemia or low blood counts. Their recommendations for treatment is central.

Lowest price per day

One tablet per day is enough bio-available iron for continual usage. Price per day is lower than competitors on the market, capsules and significantly lower then for tonics.

Heme iron tablet therapy is reasonably priced and the efficacy is sufficient especially over longer time.

Price is a fraction of the price of intravenously given iron, not to mention transfusions.

Created by FerroCare Division MediTec Group

Created By
FerroCare Division MediTec Group
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