The main interaction between the settlers and natives was trading. Indians would trade moccasin's for red paint, metal hooks for fishing, cloth, and glass beads. But, sometimes they would come across not so nice indians and the kids would lay in the wagon that were in a circle and the people with guns would fight.
What was daily life like on the trail? Well it was tough they would have to walk practically all day they would only stop to drink and eat. Sometimes they would stop to play but that was very rare.
One interesting fact is that there is a trail called the Donor Trail and people died and to stay alive they ate each other.