Functional MRI (fMRI) and EEG, ECoG, and sEEG electrophysiology signals (ephys) provide invaluable data to study brain function and disorders. However, fMRI suffers from an ill-posed temporal inverse problem due to the slow hemodynamic response, which unfolds over very slow timescales (i.e., 1-10 s) that are orders of magnitude slower than the millisecond timescales of neurons in the brain. In contrast, electrophysiology suffers from an ill-posed spatial inverse problem given the coarse spatial sampling, often outside the brain, as in EEG. Thus, combining fMRI/ephys offers in principle high temporal/spatial resolution imaging of the human brain. However, despite fMRI/ephys significant advantages, cross-modal artifacts, and other caveats have limited their widespread use. This workshop will introduce fundamental concepts and techniques in combining fMRI and electrophysiological signals, acquired both simultaneously and in separate sessions. Attendees will learn about the biological foundations, the acquisition and analysis of the fMRI/ephys signals, and the benefits and tradeoffs of different multimodal techniques. They will also learn advanced analysis techniques and select the imaging modality, including resting-state connectivity, to answer specific questions about neural decoding, cognition, and perception. Finally, the workshop will also include safety topics, such as the various computational modeling used to evaluate RF fields and the specific absorption rate (SAR) in the head with ephys leads during MRI. The SAR varies with the RF field strength, the MRI coil geometry/materials, the lead geometry/materials, the number of electrodes, and the head tissues' electrical properties. We have assembled a list of expert international speakers who will discuss the state-of-the-art and highlight recent technical developments, applications, and future directions of fMRI/ephys.
Organizer:
Giorgio Bonmassar, Ph.D. Associate Professor, AA. Martinos Center, Massachusetts General Hospital Harvard Medical School Charlestown, MA 02124. Email: Giorgio.Bonmassar@mgh.harvard.edu. Website: https://www.nmr.mgh.harvard.edu/abilab/index.php
Research interests: EEG/fMRI, micromagnetic stimulation (uMS) of excitable tissues, TMS, ECoG, and DBS/sEEG.
Lineup (October 30, 2021):
3:00-3:30 PM CDT (4:00-4:30 PM EST) Simultaneous EEG-fMRI: state of the art and current challenges. Tracy Warbrick, Ph.D. Application Specialist EEG-fMRI.
Tracy has been a member of the Brain Products team for six years and as the Application Specialist for EEG-fMRI she focuses on providing the best research and training solutions for EEG-fMRI applications. Prior to joining Brain Products, Tracy worked in academic research for several years using brain imaging methods to understand human behavior, performance, and cognition. Her main focus was on multi-modal brain imaging, specifically simultaneous EEG-fMRI.
www.linkedin.com/in/tracy-warbrick
Email: Brain Products PM_EEGfMRI <PM_EEGfMRI@brainproducts.com>
3:30-4:00 PM CDT (4:30-5:00 PM EST) Advancing the spatiotemporal resolution of neuroimaging with simultaneous EEG-fMRI. Laura Lewis, Ph.D. Associate Professor at Boston University.
Research interests: multimodal neuroimaging, high spatiotemporal resolution fMRI, sleep, thalamocortical dynamics, arousal regulation
https://www.lewisneurolab.org/
Email: Laura Lewis <ldlewis@bu.edu>
4:00-4:30 PM CDT (5:00-5:30 PM EST) Simultaneous EEG-fMRI: basic concepts and applications. Catie Chang. Assistant Professor of Electrical and Computer Engineering at Venderbilt University.
research interests: fMRI analysis, signal processing, multimodal brain imaging.
website: http://cchanglab.net
Email: catie.chang@vanderbilt.edu
4:30-5:00 PM CDT (5:30-6:00 PM EST) Measuring the functional connectome across temporal scales. Sepideh Sadaghiani, Ph.D. Assistant Professor at the University of Illinois, Urbana-Champaign.
Research interests: Multimodal connectomics, dynamic functional connectivity, cognitive control, oscillatory mechanisms.
https://connectlab.beckman.illinois.edu
Email: Sepideh Sadaghiani <sepideh@illinois.edu>
5:00-5:30 PM CDT (6:00-6:30 PM EST) From structure to function: the development of rapid interactions in the human brain. Dora Hermes, Assistant Professor in Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN.
Dora Hermes is an Assistant Professor in Physiology and Biomedical Engineering, Mayo Clinic, Rochester (MN). She studies the signals measured in the living human brain in order to identify biomarkers of neurological and neuropsychiatric diseases and develop neuroprosthetics to interface with the brain.
Research Interests: Human brain signals, fMRI, intracranial EEG, multimodal imaging, computational modeling, electrical stimulation, neuroprosthetics.
Web page: https://www.mayo.edu/research/faculty/hermes-miller-dora-ph-d/bio-20471548
Email: dorahermes@gmail.com
5:30-6:00 PM CDT (6:30-7:00 PM EST) Safety of simultaneous EEG-fMRI. Hongbae Jeong. Postdoctoral Fellow. AA. Martinos Center, Massachusetts General Hospital.
Research Interests: MRI safety, EEG-fMRI, and uMS.
Email: Jeong, Hongbae <HJEONG3@mgh.harvard.edu>
6:00-6:30 PM CDT (7:00-7:30 PM EST) Dynamics of neural representations from non-simultaneous M/EEG and fMRI signals. Santani Teng, Ph.D. Associate Scientist at Smith-Kettlewell
Research Interest: Neuroimaging, psychophysical, and applied approaches to perception and mobility. Mechanisms of visual, auditory, and tactile perceptual processing, especially in blindness. Training and assistive technology applications.
email: santani@ski.org or santani@mit.edu
lab website https://www.ski.org/lab/teng-lab
Twitter @echodislocation