Spinal Muscular atrophy is a disease in which the spinal cord nerves don't receive signals and thus the spine gets smaller. Chromosome 5 SMA has a wide variability due to that there are types 1-4. Children who have symptoms of this at birth usually have type 1. This disease makes the lower body not have any maneuverability so their wheel chair is their bed. Chromosome 5 SMA is caused by a deficiency of a motor neuron protein called SMN, for “survival of motor neuron.” ( https://www.mda.org/disease/spinal-muscular-atrophy) If the protein isn't there as implied it won't work. The primary symptom of chromosome 5-related (SMN-related) SMA is weakness of the voluntary muscles. The muscles most affected are those closest to the center of the body, such as those of the shoulders, hips, thighs and upper back. These forms vary greatly in severity and in the muscles most affected. This can be a serious disease and cause unbearable pain which may lead to death depending on the type. So far there is not a big enough cure to get rid of SPA but Research has focused on strategies to increase the body's production of SMN protein, lacking in the chromosome 5-related forms of the disease. To sum it all up this disease has no cure yet, and it robs people of their physical strength causing the motor nerve cells in the spinal cord taking away the ability to walk, eat and breathe. It is also the number one cause of death for infants.