Alzheimer's Disease Sierra Courier; Period 4

A. Alzheimer's is an inherited genetic disorder. There are two different type of Alzheimer's disease. One type is called Early-onset. Early-onset is caused by any one of a number of different single gene mutations on chromosomes 21, 14, and 1. The other type of Alzheimer's is called Late-onset. Late-onset is not found in any direct gene, but it is found that chromosome 19 does increase the risk of Alzheimer's.

B. Alzheimer's is found in the Hippocampus, that is the part of the brain essential in forming memories. The chromosome APP, Amyloid Precursor Protein, and PS-1 , Presenilin 1, are found in Alzheimer's.

C. Phenotype's of Late-onset Alzheimer's disease include memory lost, confusion, behavior and mood changes, and eventually they have trouble with speaking, swallowing, and walking. However, microscopic changes occur in the brain long before clinical symptoms arise, as abnormal structure spread through the brain and damage the nerve cells ( Plaques and Tangles).

D. While there is no single test that can diagnosed Alzheimer's, there are steps taken to help. A doctor will do a medical history, mental status testing, a physical and neurological exam, and blood tests and brain imaging.

E. Currently, there is no cure for Alzheimer's but there are treatments available that help the ability to think and how a person acts. There are medications available that help treat memory loss and confusion but medication can not stop or prevent the damage.

F. Yes, Alzheimer is a inheritable gene that can be passed down from generation to generation.

SOURCES:

www.nia.nih.gov

www.ncbi.nlm.nih.gov

www.alz.org

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