Queen's rookie Nick Alie Day scored early to put the hosts ahead.
RMC keeper Johnathan Ardell faced six shots in the first half.
The Paladins were behind 3-0 at the break.
RMC earned six corners in the match, but their attempts were all turned away from goal.
Jeremy McBride earned his second yellow of the match in the 89th minute, putting the Paladins down to 10 men on a cumulative red card as the game ended.
With a final score of 5-0 for Queen's, RMC will look to bounce back against tough competition on Reunion Weekend. The Paladins host Ryerson on Saturday and Toronto on Sunday. Both games are at 3:15 PM on Navy Bay 5.