"Come, you spirits that tend on mortal thoughts, unsex me here." (1.5.38-39)
She is determined to be Queen, so to help her become Queen, she asks that the spirits change her to a man because a women couldn't kill.
"My thought, whose murder yet is but fantastical,
Shakes so my single state of man
That function is smothered in surmise,
And nothing is but what is not." (1.3.152-155)
Macbeth at the beginning of the play is afraid of his intrusive thoughts when he begins to contemplate murder to reach higher positions of power. This contrasts who he becomes later in the play.
" I laid their daggers ready; he could not miss 'em. Had he not resembled my father as he slept, I had done't" (2.2.11-13)
She is showing her dominance by putting Macbeth down and saying she would've done it if he hadn't looked like he father. Thus making Macbeth feel like less of a man.
“Glamis hath murdered sleep, and therefore
Shall sleep no more. Macbeth shall sleep no more.” (2.2.55-57)
Macbeth murdered the then King Duncan while he was asleep and is now very guilty. This marks the beginning of his downfall as an honorable man.
"You must leave this be." & "What's to be done?" (3.2.35 & 45)
In these quotes, Lady Macbeth is losing control of Macbeth and now he's killing without her knowledge.
"What, quite unmanned in folly." (3.4.74)
Even though she is losing control of Macbeth, she still tries to control him be questioning his manhood yet again. This doesn't work however and this is when she no longer has any control of him.
"I am in blood
Stepped in so far that, should I wade no more,
Returning were as tedious as go o’er." (3.4.136-138)
Macbeth has killed so many people and is so paranoid now to keep the power he's obtained through murder that he feels he's done too much to stop now and make everything that he's done be all for nothing. He has nearly become numb to killing.
"The castle of Macduff I will surprise,
Seize upon Fife, give to th’ edge o’ th’ sword
His wife, his babes, and all unfortunate souls
That trace him in his line." (4.1.150-153)
Macbeth has become such a blood-thirsty, power-hungry tyrant that he plans to murder all people related to Macduff by surprise. He uses murder as his primary tactic to keep his power at this point.
"Out damned spot! Out, I say! One: Two: why, then 'tis time to do't. Hell is murky." (5.1.31-32)
At the beginning of the story, Lady Macbeth tells Macbeth that a little water clears of this deed. Physically it worked but the guilt was still there. Now she has gone crazy from the guilt.
"The Queen, my lord, is dead." (5.5.16)
Lady Macbeth eventually kills herself because she can no longer deal with the guilt.
"I have supped full with horrors.
Direness, familiar to my slaughterous thoughts,
Cannot once start me." (5.5.13-15)
Macbeth is now numb to the horrific acts he's done. He's formed a tolerance to the things he's done in order to live with himself. He has gone from being a man simply afraid of the thought of murdering someone for power at the beginning of the play to someone who has killed so many people and committed so many terrible acts that he's not longer upset by it.