Silver ions effective in cancer treatment NONTOXIC TO NONCANCEROUS OTHER CELLS

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells.

Int J Nanomedicine. 2015 Jun 11;10:3937-53. doi: 10.2147/IJN.S80349. eCollection 2015 Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN.

"We show that AgNPs are highly cytotoxic toward TNBC cells at doses that have little effect on nontumorigenic breast cells or cells derived from liver, kidney, and monocyte lineages. AgNPs induced more DNA and oxidative damage in TNBC cells than in other breast cells. In vitro and in vivo studies showed that AgNPs reduce TNBC growth and improve radiation therapy. These studies show that unmodified AgNPs act as a self-therapeutic agent with a combination of selective cytotoxicity and radiation dose-enhancement effects in TNBC at doses that are nontoxic to noncancerous breast and other cells."
Nontoxic to noncancerous cells

Differential Cytotoxic Potential of Silver Nanoparticles in Human Ovarian Cancer Cells and Ovarian Cancer Stem Cells.

Int J Mol Sci. 2016 Dec 12;17(12). pii: E2077. Choi YJ, Park JH, Han JW, Kim E, Jae-Wook O, Lee SY, Kim JH, Gurunathan S.

"In particular, AgNPs showed significant cytotoxic potential in ALDH⁺/CD133⁺ subpopulations of cells compared with other subpopulation of cells and also human ovarian cancer cells (bulk cells). These findings suggest that AgNPs can be utilized in the development of novel nanotherapeutic molecules for the treatment of ovarian cancers by specific targeting of the ALDH⁺/CD133⁺ subpopulation of cells."
nanotherapeutic molecules for the treatment of cancers

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy.

Int J Nanomedicine. 2015 Jun 29;10:4203-22. doi: 10.2147/IJN.S83953. eCollection 2015. Gurunathan S, Park JH, Han JW, Kim JH.

"We have demonstrated a simple approach for the synthesis of AgNPs using the novel strains B. tequilensis and C. indica, as well as their mechanism of cell death in a p53-dependent manner in MDA-MB-231 human breast cancer cells. The present findings could provide insight for the future development of a suitable anticancer drug, which may lead to the development of novel nanotherapeutic molecules for the treatment of cancers."
AG-Nps do not cause adverse effects

Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface

Part Fibre Toxicol. 2013 Apr 4;10:11. doi: 10.1186/1743-8977-10-11. Herzog F, Clift MJ, Piccapietra F, Behra R, Schmid O, Petri-Fink A, Rothen-Rutishauser B.

"With an experimental setup reflecting physiological exposure conditions in the human lung more realistic, the present study indicates that Ag-NPs do not cause adverse effects and cells were only sensitive to high Ag-ion concentrations."
exploring new therapeutic applications

Comparison of cytotoxicity and genotoxicity effects of silver nanoparticles on human cervix and breast cancer cell lines.

Hum Exp Toxicol. 2016 Nov 4. pii: 0960327116675206. [Epub ahead of print] Juarez-Moreno K, Gonzalez EB, Girón-Vazquez N, Chávez-Santoscoy RA, Mota-Morales JD, Perez-Mozqueda LL, Garcia-Garcia MR, Pestryakov A, Bogdanchikova N.

"We conclude that, Argovit (polyvinylpyrrolidone-coated AgNPs) induce a cytotoxic effect in a time and dose-dependent manner in all the eight cancer cell lines tested. Nevertheless, the genotoxic effect is mainly restricted by the concentration effect. The results contribute to explore new therapeutic applications of AgNPs for malignances in murine models and to study in deep the cytotoxic and genotoxic effects of AgNPs in healthy cells at the surrounding tissue of the neoplasia."
Significant enhancement in killing tumor cells

TAT-modified nanosilver for combating multidrug-resistant cancer.

Biomaterials. 2012 Sep;33(26):6155-61. doi: 10.1016/j.biomaterials.2012.05.035. Epub 2012 Jun 8. Liu J, Zhao Y, Guo Q, Wang Z, Wang H, Yang Y, Huang Y.

"Of note, AgNP-TAT showed significant enhancement in killing tumor cells, e.g. up to 24 fold higher compared to its counterpart without TAT-modification. The animal studies further confirmed the success of our strategy that AgNP-TAT was able to effectively inhibit the tumor growth in the mice bearing malignant melanoma at a dose of 1 nmol/kg, compared with the effective dose (4.3 μmol/kg) of doxorubicin. AgNP-TAT also showed significantly reduced adverse toxicity in vivo. It indicates AgNP-TAT could be a class of nano drug for MDR cancer treatment."
novel chemotherapeutic approaches

Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis.

Sci Rep. 2016 Jun 13;6:27902. doi: 10.1038/srep27902. Kovács D, Igaz N, Keskeny C, Bélteky P, Tóth T, Gáspár R, Madarász D, Rázga Z, Kónya Z, Boros IM, Kiricsi M.

"According to our findings AgNPs are able to kill osteosarcoma cells independently from their actual p53 status and induce p53-independent cancer cell apoptosis. This feature renders AgNPs attractive candidates for novel chemotherapeutic approaches."
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FerroCare Division of MediTec Group de ideias
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