Comparison of cytotoxicity and genotoxicity effects of silver nanoparticles on human cervix and breast cancer cell lines.
Hum Exp Toxicol. 2016 Nov 4. pii: 0960327116675206. [Epub ahead of print] Juarez-Moreno K, Gonzalez EB, Girón-Vazquez N, Chávez-Santoscoy RA, Mota-Morales JD, Perez-Mozqueda LL, Garcia-Garcia MR, Pestryakov A, Bogdanchikova N.
"We conclude that, Argovit (polyvinylpyrrolidone-coated AgNPs) induce a cytotoxic effect in a time and dose-dependent manner in all the eight cancer cell lines tested. Nevertheless, the genotoxic effect is mainly restricted by the concentration effect. The results contribute to explore new therapeutic applications of AgNPs for malignances in murine models and to study in deep the cytotoxic and genotoxic effects of AgNPs in healthy cells at the surrounding tissue of the neoplasia."