Silver against Tuberculosis colloidal silver effective

Antituberculous effect of silver nanoparticles

Journal of Physics: Conference Series, Volume 291, Number 1. G N Kreytsberg, I E Gracheva, B S Kibrik and I V Golikov

"The in vitro experiment, involving 1 164 strains of the tuberculosis mycobacteria, exhibited a potentiating effect of silver nanoparticles on known antituberculous preparations in respect of overcoming drug-resistance of the causative agent."

"The performed research scientifically establishes efficacy and safety of the nanocomposite application in combination therapy of patients suffering from drug-resistant tuberculosis."

Anti-mycobacterial properties and bactericidal mechanisms

Mixed metal oxide nanoparticles inhibit growth of Mycobacterium tuberculosis into THP-1 cells.

Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S181-S183. doi: 10.1016/j.ijmyco.2016.09.011. Epub 2016 Nov 5. Jafari AR, Mosavi T, Mosavari N, Majid A, Movahedzade F, Tebyaniyan M, Kamalzadeh M, Dehgan M, Jafari S, Arastoo S.

"Humans have been in a constant battle with tuberculosis (TB). Currently, overuse of antibiotics has resulted in the spread of multidrug-resistant Mycobacterium tuberculosis (MDR), leading to antibiotic ineffectiveness at controlling the spread of TB infection in host cells and especially macrophages. Additionally, the Mycobacterium tuberculosis (Mtb) has developed methods to evade the immune system and survive."

"With the discovery of nanoparticle (NP)-based drugs, it is necessary to research their anti-mycobacterial properties and bactericidal mechanisms. In this study, we synthesized mixed metal oxide NPs and tested their ability to inhibit Mtb growth into macrophages and investigated the cytotoxic effects of NPs in THP-1 cells."

Silver is one of the most universal antimicrobial substances

Fabrication of Silver Nanoparticles and Their Antimicrobial Mechanisms

European Cells and Materials Vol. 11. Suppl. 1, 2006 (page 58) H.Y Song,, K.K Ko, I.H Oh, B.T Lee

"Silver is one of the most universal antimicrobial substances. Nano-technology enables us to expand the surface area of silver particles markedly. They showed excellent antibacterial activity. Antimicrobial mechanisms of nanosilver were different according to the species of bacteria. From the result, Silver nanoparticles will be available as a good antibiotic alternative."

Excellent antibacterial activity against clinically isolated ESBL-strain

Biosynthesis of Monodispersed Silver Nanoparticles and their Activity against Mycobacterium tuberculosis

J Nanomed Biotherapeut Discov 3:110. doi:10.4172/2155-983X.1000110 Banu A, Rathod V

"Living organisms have huge potential for the production of silver nanoparticles and nanodevices of wide applications. This study demonstrated the green synthesis of silver nanoparticles and their activity against ESBL strains."

"The synergistic effect of biosynthesized silver nanoparticles with antibiotics has shown the excellent antibacterial activity against clinically isolated ESBL-strain."

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SilverLife Division of MediTec Group de ideias
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Credits:

Created with images by NIAID - "Mycobacterium tuberculosis Bacteria" • NIAID - "Mycobacterium tuberculosis Bacteria, the Cause of TB" • NIAID - "Mycobacterium tuberculosis Bacteria, the Cause of TB" • US Army Africa - "USAMRUK Malaria Diagnostics and Control Center of Excellence microscopy training - Nigeria, Africa, September 2009"

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