Mixed metal oxide nanoparticles inhibit growth of Mycobacterium tuberculosis into THP-1 cells.
Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S181-S183. doi: 10.1016/j.ijmyco.2016.09.011. Epub 2016 Nov 5. Jafari AR, Mosavi T, Mosavari N, Majid A, Movahedzade F, Tebyaniyan M, Kamalzadeh M, Dehgan M, Jafari S, Arastoo S.
"Humans have been in a constant battle with tuberculosis (TB). Currently, overuse of antibiotics has resulted in the spread of multidrug-resistant Mycobacterium tuberculosis (MDR), leading to antibiotic ineffectiveness at controlling the spread of TB infection in host cells and especially macrophages. Additionally, the Mycobacterium tuberculosis (Mtb) has developed methods to evade the immune system and survive."
"With the discovery of nanoparticle (NP)-based drugs, it is necessary to research their anti-mycobacterial properties and bactericidal mechanisms. In this study, we synthesized mixed metal oxide NPs and tested their ability to inhibit Mtb growth into macrophages and investigated the cytotoxic effects of NPs in THP-1 cells."