-Tay-Sachs is an inherited disorder that destroys neurons in both the brain and the spinal cord. Tay-Sachs occurs due to a mutation in the HEXA gene, which carries instructions for making a portion of an enzyme called HEX-A. Mutations in the HEXA gene disrupts HEX-A from breaking down GM2 gangliosides. A person with this disease might show these symptoms:muscle weakness, hearing loss, vision loss,consistent faints and more.