pure Red Cell AplAsia By: brian gonzalez Period 2

Pure Red Cell Aplasia is a rare disease that affects bone marrow and its production of red blood cells.

DISEASE STATISTICS: Pure Red Cell Aplasia is very rare. There has been 37 patients with Pure Red Cell Aplasia from 1966 to 1982. I was not able to find a more recent study of people who have the disease. This disease can be found in both males and females equally. It is not found with in a specific ethnic group. National Organization for Rare Disorders also known as NORD is an organization that helps find funding to research PRCA and other diseases. Genetic and Rare Diseases Information Center (GARD) researches Pure Red Cell Aplasia and other rare diseases.

SYMPTOMS & INHERITANCE: Having PRCA causes bone marrow to produce a reduced number of red blood cells. It gives the patient anemia. General weakness is a symptom of having PRCA. Changes in skin and eye color occur. PRCA negatively affects the patient's growth. Pure Red Cell Aplasia is not inherited but there is a type called Diamond-Blackfan Anemia which can be inherited.

DIAGNOSIS: Examining a patients bone marrow to how healthy it is. Counting the total number of blood cells to the type of blood in the body. Looking at the patients medical history and physical examination will help understand the cause. Place of birth can also determine if there is any infection.

TREATMENTS: Corticosteroids are the initial treatment for PRCA but the doses have severe side effects. If the cause of Pure Red Cell Aplasia is an autoimmune-related disorder than medication can be used to reduce symptoms. Patients who do not respond positively to other treatments may need to rely on blood transfusions on a regular bases. Blood transfusions are used to increase red blood cell levels.

ETHICAL: I do not see anything wrong with the treatments and diagnosis being preformed on someone who is concise of what he/she is doing. Anyone having PRCA is going to have a difficult life. If I had PRCA my life would be shortened which no one would like. I have spent most of my life in school like most kids so I would not be able to do much. Moving around would be difficult even simple movements. I live a very sedentary lifestyle so I don't think much would change. In summer I go out a lot so I would be very angry, frustrated, and sad.

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