Low-dose vs. High-dose Why Low-dose is more efficient than High-dose when it comes to iron

Restoring counts take time

Restoring iron values takes a while, just like the onset and development of iron deficiency doesn't happen overnight. It is a question of balance where the uptake of iron needs to match the losses. Natural losses include for instance loss of blood through menstruation and natural intake is based on the diet.

it takes a while

Natural dose

The regular amount of iron we need in a mixed diet is 12 - 18 mg in total per day. In healthy individuals the average iron demand is 1 mg daily for men, 1.5 - 2.5 mg daily for women and during pregnancy 2-3 mg daily corresponding to a total of 500 - 1 000 mg, which will be absorbed from the daily diet.

Normally the regular diet is enough

If our intake is lacking this amount or the losses are larger, iron deficiency will eventually develop

A normal adult carries 3,5 – 4 g iron (3 500 – 4 000 mg), so a turnover of less than 20 mg per days means a situational change. This is the natural state and the body is not adopted to having the normal turnover increased many times. In normal health iron management in the body is conservative with little or no loss of body iron save 1 - 2 mg being excreted, principally by sloughing of cells from the gastrointestinal tract and skin, and menstruation.

Normal intake is over 20 mg per day

Iron absorption

Most of the daily iron will be in non-heme form, which is bound in plants or bound chemically in the regular syntethic supplements.

Non-heme iron is not very bioavailable, so more than 95 % will not be absorbed.

Heme iron is taken up at a significantly higher rate and will not produce side-effects like the synthetic supplements. It is also not affected by other simultaneously ingested food or drink.

Only two kinds of bio-available iron

Uptake of Non-Heme iron

30 days of supplementation with 100 mg Fe++ non-heme iron at a bio-availablity of 2 % theoretically gives 60 mg absorbed iron. At 4 %, which is unusual, the amount is 120 mg. Non-heme supplements at 100 mg Fe++ per dose regularly have an incidence of side-effects leading to termination of the therapy of around 30 %. Donors that have previous negative experiences will usually not take the supplements at all.

Uptake of Heme iron

Supplementation with 18 mg of heme iron for thirty days with a bio-availability/uptake of 20 % gives 108 mg of absorbed iron. Heme iron is very well tolerated and is known to have a side-effects ratio as placebo. This means a higher therapy success rate. This is why heme iron tablets with a dose of 18 mg Fe++ can compete with non-heme tablets of 100 mg Fe++.

The mineral Zinc is also vital for life

More than 60 mg non-heme stops zinc uptake

A dose of more than 60 mg of non-heme iron per day will block the uptake of Zinc, which is an essential trace element vital for many biological functions and that has a crucial role in the enzyme system in the body. Heme iron will not affect the uptake of Zinc.

Synthetic/Artificial supplements

Syntethic supplements in high doses

There is a clear tendency to use non-heme iron supplements in very large doses because many believe a strong deficiency situation should be cured as quickly as possible. However there is a large risk for therapy-ruining side-effects and a normal uptake will not permit a large change quickly. A steady therapy with an efficient and well tolerated iron, such as heme iron in tablet form, is therefore always preferable.

The OptiFer® series of heme iron supplements are based on natural bovine heme iron and will safely and efficiently keep iron counts at an optimal level

www.optifer.international www.hemeiron.com

Created By
FerroCare Division MediTec Group de ideias
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