Research from the NI's Segal Lab provides new hope for recovery from degenerative neurological diseases — such as ALS and multiple sclerosis — as well as from damage caused by traumatic brain and spine injuries and stroke. Researchers examined a novel type of immune cell that not only prevents further damage of the central nervous system, but also reverses damage and restores function.
Photo: Dr. Benjamin Segal (left) and Dr. Andrew Sas examine the properties of a newly-discovered cell in a lab at The Ohio State University Wexner Medical Center.
Research Into the Long-term Effects of Traumatic Brain Injury
Brain injury negatively influences both life-span and health-span and has far-reaching effects on survivors and their caregivers.
Researchers at the Godbout Laboratory are examining the long-term consequences of brain injury, with a focus on inflammatory processes that persist in the brain and impair brain homeostasis.
Did you know?
5 million Americans are living with serious long-term traumatic brain injury (TBI) related deficits.
75-70% of TBI patients continue to have secondary cognitive and behavioral complications after TBI.
Learn more: godboutlaboratory.com
Department of Neurosurgery
Finding new treatments for Parkinson’s disease
In collaboration with the University of California, Berkeley, researchers at the Department of Neurosurgery are working to use a recently “Nobel” awarded CRISPR technology (“genetic scissors”) for editing defective genes in the brain. With a combination of advanced neurosurgical delivery and novel nanoparticles formulations to delete malfunctioning genes, we hope to be able to use this approach in a large number of incurable brain diseases, such as Huntington’s, Alzheimer’s and Parkinson’s disease, that are caused by the over-expression (overproduction) of pathogenic proteins.
The current animal models of Parkinson’s disease (PD) are imperfect and perhaps that is why it is so difficult to design successful treatments for this debilitating disease. We are working to create a new PD mouse model (with deleted B4galnt1 gene) that would represent a true pathophysiological model of PD, the most faithful recapitulation of the human disease yet seen in an animal model. The pilot experiments have already shown a truly disease-modifying strategy of gene therapy.
Learn more: go.osu.edu/neurosurgery-research
The Connection Between Obesity, Diabetes, Aging and the Nervous System
The Townsend Laboratory for Neurobiology and Energy Balance is engaged in the full spectrum of biomedical research – from basic science unraveling physiological processes, to translational projects moving their way to human patients. We are exploring how the plasticity, or remodeling, of the brain and peripheral nerves impacts metabolic health, with the goal of preventing or reversing conditions like diabetes, obesity, and cardiovascular disease – including with aging.
Learn more: ktownsendlab.com
Department of Psychiatry and Behavioral Health
Recovery and Resilience
In the above video, Dr. Craig Bryan explains how his experiences working with members of the military changed the way he approaches mental healthcare.
Suicide researchers have traditionally been guided by the question, “Why do people die by suicide?” Our research is guided by a somewhat different question: “What keeps people alive when they want to die?” This subtle but important shift in focus has been critical to our program’s success.
The Division of Recovery and Resilience focuses on conducting innovative research focused on understanding the individual and social factors that promote growth and resilience, while also translating scientific discoveries into practical strategies to improve the lives of individuals and communities.
Our researchers have developed treatments proven to reduce suicide attempts by up to 76% and have designed new methods for identifying patients in need. Our clinicians use these cutting-edge methods to help individuals rapidly resolve suicidal crises and create meaningful lives.
Learn more: go.osu.edu/recovery-resilience
Researching the Connections Between Cancer, its Treatments and the Brain
The Pyter Laboratory is focused on the connections between behavioral neuroscience and cancer immunology. The core causes of behavioral issues in cancer patients are unknown, although tumor biology, cancer treatments, and/or stress can each contribute. This lack of knowledge means that successful cancer treatment falls short of its potential and prior quality of life remains elusive for survivors.
Facts and Figures
Due to improved diagnostics and treatments, about 70% of today's cancer patients will survive for at least 5 years. (NCI)
More than 16.9 million cancer survivors are alive today. (American Cancer Society)
About 1 in 5 cancer survivors become depressed (NCI), more than twice as much as healthy adults.
Nearly 2/3 of patients with breast cancer experience some sort of mood disorder.
Studies of cancer patients followed for 15 years show that depression is the most consistent psychological predictor of a shorter survival time.
“The location of the new facility [west of Kenny Road and south of Lane Avenue] accelerates the translation of cutting-edge research discoveries from the laboratory bench to the patient bedside,” said Dr. Hal Paz, executive vice president and chancellor for Health Affairs at Ohio State and CEO of the Ohio State Wexner Medical Center. “Proximity to patients is key and all of Ohio State’s physicians will immediately incorporate the latest advances in diagnosis and treatment.”