Silver vs. HIV cytoprotective activities toward HIV-infected cells

Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells.

Chem Commun (Camb). 2005 Oct 28;(40):5059-61. Epub 2005 Sep 16. Sun RW, Chen R, Chung NP, Ho CM, Lin CL, Che CM.

"Silver nanoparticles fabricated in Hepes buffer exhibit potent cytoprotective and post-infected anti-HIV-1 activities toward Hut/CCR5 cells."
Silver nanoparticles exert anti-HIV activity

Mode of antiviral action of silver nanoparticles against HIV-1.

J Nanobiotechnology. 2010 Jan 20;8:1. doi: 10.1186/1477-3155-8-1. Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L, Rodriguez-Padilla C.

"Our data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cell-free virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle." "These properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains."
Silver nanoparticles inhibit the virus from binding to host cells

Interaction of silver nanoparticles with HIV-1.

J Nanobiotechnology. 2005 Jun 29;3:6. Elechiguerra JL, Burt JL, Morones JR, Camacho-Bragado A, Gao X, Lara HH, Yacaman MJ.

"The interaction of nanoparticles with biomolecules and microorganisms is an expanding field of research. Within this field, an area that has been largely unexplored is the interaction of metal nanoparticles with viruses. In this work, we demonstrate that silver nanoparticles undergo a size-dependent interaction with HIV-1, with nanoparticles exclusively in the range of 1-10 nm attached to the virus."
Inhibition of cell-associated HIV-1 infection

Use of silver nanoparticles increased inhibition of cell-associated HIV-1 infection by neutralizing antibodies developed against HIV-1 envelope proteins.

J Nanobiotechnology. 2011 Sep 18;9:38. doi: 10.1186/1477-3155-9-38. Lara HH, Ixtepan-Turrent L, Garza Treviño EN, Singh DK.

"The addition of AgNPs to NABs has significantly increased the neutralizing potency of NABs in prevention of cell-associated HIV-1 transmission/infection. Further exploration is required to standardize potentiation of NABs by AgNPs. It is also required to evaluate in vivo toxicity of AgNPs before AgNPs could be incorporated in any antiviral vaginal creams."
New therapeutic horizons

Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds.

J Nanobiotechnology. 2011 Aug 3;9:30. doi: 10.1186/1477-3155-9-30. Lara HH, Garza-Treviño EN, Ixtepan-Turrent L, Singh DK.

"AgNPs has been studied particularly on HIV where it was demonstrated the mechanism of antiviral action of the nanoparticles as well as the inhibition the transmission of HIV-1 infection in human cervix organ culture."
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FerroCare Division of MediTec Group de ideias
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Created with images by lechenie-narkomanii - "freedom sky hands" • NIAID - "HIV-infected T cell" • NIAID - "HIV-infected T cell" • glitterfighter - "IASC 2012" • glitterfighter - "IASC 2012"

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