Lyme disease is caused by an intracellular parasite that activates an undesirable protein complex called NFKB.
Active in disease states, NFKB causes a cascade of superoxide-producing oxidases that cause increased vasoreactivity. This vasoreactivity leads to symptoms such as local vasoconstriction and neuronal dysactivity. In everyday language, NFKB is bad news.
Unfortunately, even patients who have treated their Lyme disease with antibiotics may suffer from a continuous, long-term activation of NFKB. In this case, patients may experience symptoms that they feel are related to active Lyme disease, even though the disease has been cured.
Help is available. NRF2, the good news, counteracts the continuous activation of NFKB by releasing antioxidant stress enzymes and anti-inflammatory cytokines.
Treatments include OTC benfotiamine, which inhibits NFKB activation. Benfotiamine is a fat-soluble derivative of vitamin B1. Another form of B1, allithiamine, is found in garlic and may help relieve symptoms. Black rice also inhibits NFKB and activates NRF2. Finally, OTC pycnogenol and astaxanthin, an antioxidant derived from krill shrimp and oil may help.