The dose makes the poison.
"What is it that is not poison? All things are poison and nothing is without poison. It is the dose only that makes a thing not a poison." Paraceilsus (1493-1541)
Understand the toxicity of pesticides.
All synthetic pesticides are designed to control pests, but they can also be toxic (poisonous) to desirable plants and animals, including humans. Some pesticides are so highly toxic that very small quantities can kill a person, while exposure to a sufficient amount of most pesticides can make a person ill. Since even fairly safe pesticides can irritate the skin, eyes, nose, or mouth, it is a good idea to understand how pesticides can be toxic so you can follow practices designed to reduce or eliminate your exposure and the exposure of others to them.
Dermal (skin) exposure accounts for about 90% of the exposure pesticide users receive from non-fumigant pesticides. It may occur any time a pesticide is mixed, applied, or handled and it often goes undetected.
The seriousness of dermal exposure depends upon : (a) The dermal toxicity of the pesticide; (b) Rate of absorption through the skin; (c) Size of the skin area contaminated; (d) Length of time the material is in contact with the skin; and (e) Amount of pesticide on the skin.
Rates of absorption through the skin are different for different parts of the body. Absorption continues to take place on all of the affected skin area as long as the pesticide is in contact with the skin. The seriousness of the exposure is increased if the contaminated area is large or if the material remains on the skin for a period of time.
Toxicity refers to the ability of a chemical substance to damage body organs or disrupt the metabolism of living tissues. These adverse effects may range from slight symptoms such as headaches to severe symptoms like coma, convulsions, or death. Poisons work by altering normal body functions. Most toxic effects are naturally reversible and do not cause permanent damage if prompt medical treatment is sought. Some poisons, however, cause irreversible (permanent) damage.
Toxicity is usually divided into two types, acute or chronic, based on the number of exposures to a poison and the time it takes for toxic symptoms to develop. Acute toxicity is due to short-term exposure and happens within a relatively short period of time, whereas chronic exposure is due to repeated or long-term exposure and happens over a longer period. Acute - usually one time and is Immediate (minutes to hours). Chronic - more than a few times and a week to years.
The acute toxicity of a chemical refers to its ability to do systemic damage as a result of a one-time exposure to relatively large amounts of the chemical. A pesticide with a high acute toxicity may be deadly if even a very small amount is absorbed. The signal words on the label are based on the acute toxicity of the pesticide. Acute toxicity may be measured as acute oral (through the mouth), acute dermal (through the skin) or acute inhalation (through the lungs or respiratory system).
Acute toxicity measurements.
The commonly used term to describe acute toxicity is LD50. LD means lethal dose (deadly amount) and the subscript 50 means that the dose was acutely lethal to 50% of the animals to which the chemical was administered under controlled laboratory conditions. The test animals are given specific amounts of the chemical in either one oral dose or by a single injection, and are then observed for a specified time.
The lower the LD50 value, the more acutely toxic is the pesticide. Therefore, a pesticide with an oral LD50 of 500 mg/kg would be much less toxic than a pesticide with an LD50 of 5 mg/kg. LD50 values are expressed as milligrams per kilogram (mg/kg), which means milligrams of chemical per kilogram of body weight of the animal.
LD50 values are generally expressed on the basis of active ingredient. If a commercial product is formulated to contain 50 percent active ingredient, it would take two parts of the material to make one part of the active ingredient. In some cases, other chemicals mixed with the active ingredient for formulating the pesticide product may cause the toxicity to differ from that of the active ingredient alone.
Acute inhalation toxicity is measured by LC50. LC means lethal concentration. Concentration is used instead of dose because the amount of pesticide inhaled in the air is being measured. LC50 values are measured in milligrams per liter. The lower the LC50 value, the more toxic is the pesticide.
There is also LT50 and this is LD50 and LC50 but over time.
Our Product's LD50 is >42,880 mg/kg. One of the highest LD50 values, which means it is much safer than most, as it has one of the lowest acute toxicity measurement.
Label ID of acute toxicity.
It is important to read the label to look for signal words identifying the product's acute toxicity. To alert pesticide users to the acute toxicity of a pesticide, a signal word may appear on the label. Four different categories are used.
Danger - Warning - Caution - No Label
Signal words are used to tell the user whether the chemical is highly toxic, moderately toxic, slightly toxic, or relatively non-toxic. These label warnings are based, for the most part, on the chemical's acute toxicity. For example, the acute oral and acute dermal toxicity of a pesticide may be in the slightly toxic category. But if the acute inhalation toxicity is in the highly toxic category, the pesticide label will have the signal words for a highly toxic pesticide. The degree of eye or skin irritation caused by the pesticide also influences the signal word.
Our Product's Signal Word is "Caution".
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