Sammie Bachrodt opened the game with a pair of three-pointers to give the Bulldogs an early lead.
Lizzy Wendell scored two points as part of a 7-0 run by the Bulldogs to pull within a basket.
Wendell added a three-pointer minutes later to give the Drake fans plenty to cheer about.
The Bulldogs outscored K-State in the second quarter to head into halftime trailing 30-25.
Playing in her first NCAA game, freshman Becca Hittner scored five of her 13 points during the third quarter while trying to hold senior All-Big 12 center Breanna Lewis in check.
Lizzy Wendell scored seven points down the stretch, but the Bulldogs could get no closer than seven points in the final minutes.
The team gathers on the court for the final time to cap a historic season that came to an end with the 67-54 loss at K-State
I am really proud of our team and I am really proud of our senior class for taking us on this amazing journey this season ... We are still going to continue to learn, grow and get better. The best is still coming but the legacy that the senior class has left has been phenomenal.” - Jennie Baranczyk.
“I could not ask for a better college career here at Drake. Choosing Drake was the best thing I could have done for the last four years here. Being able to build it up and end on a season like this with people that are so fun to be around is really special. It makes everything worth it. Today is not how we wanted to go out but being able to reflect and look back on the season is pretty amazing. I could not ask for a better season and a better senior year." - Lizzy Wendell