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<title><italic>CG4715</italic>/<italic>Iris</italic> Relationships to Viral <italic>Envelope</italic> Genes</title><p>(A) The central domains of <italic>CG4715</italic> and related viral <italic>env</italic> genes were aligned, and a neighbor-joining phylogenetic tree constructed. The tree separates the <italic>CG4715-env</italic> superfamily into four groups: the baculoviruses, the BEL clade retroviruses <italic>roo</italic> and <italic>Kanga,</italic> the <italic>gypsy</italic>-like retroviruses, and host genome borne <italic>CG4715</italic> orthologs in <italic>Drosophila</italic> and mosquito genomes. While the tree overall does not provide high resolution to discern the order of divergence of each of the clades, there is very strong phylogenetic resolution (bootstrap support of key nodes shown) to unambiguously group <italic>CG4715</italic> orthologs with the <italic>Kanga</italic> retrovirus lineage, indicating that this lineage of retroviruses is the likely source of the <italic>CG4715</italic> lineage.</p><p>(B) Neighbor-joining phylogeny of selected representatives from the BEL clade of retrotransposons indicates that the <italic>Kanga</italic> retroviruses from <italic>Drosophila</italic> genomes form a monophyletic clade (the presumed ancestor of <italic>CG4715</italic> is indicated by a yellow oval). Most retrotransposons in the BEL lineage do not possess an <italic>env</italic> gene (blue lettering) while many elements that do (red) have acquired non-homologous <italic>env</italic> genes acquired from a different viral source [<xref ref-type="bibr" rid="pgen-0010044-b19">19</xref>,<xref ref-type="bibr" rid="pgen-0010044-b20">20</xref>].</p>
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